NEOCYST CONSORTIUM UNIVERSITY OF MÜNSTER UNIVERSITY OF COLOGNE HANNOVER MEDICAL SCHOOL HUB – HANNOVER UNIFIED BIOBANK UNIVERSITY OF DUISBURG – ESSEN UNIVESITY HOSPITAL GIESSEN – MARBURG CENTER FOR HUMAN GENETICS, MAINZ UNIVERSITY HOSPITAL FRANKFURT & DKFZ HEIDELBERG UNIVERSITY HOSPITAL HEIDELBERG UNIVERSITY OF FREIBURG